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논문.htm
Immunohistochemical study on the distribution of neuronal nitric oxide synthase-immunoreactive neuro
Journal of Molecular Histology Publisher: Springer Science+Business Media B.V., Formerly Kluwer Academic Publishers B.V. ISSN: 1567-2379 (Paper) 1573-6865 (Online) DOI: 10.1007/s10735-005-9001-x Issue: Volume 36, Number 5 Date: June 2005 Pages: 325 - 329 Immunohistochemical study on the distribution of neuronal nitric oxide synthase-immunoreactive neurons in the spinal cord of aged rat Yoon Hee Chung1 , Daejin Kim1, Keum Jung Lee1, Sung Su Kim1, Kyung Yong Kim1, Dai-Yun Cho2, Dong Suep Sohn2 and Won Bok Lee1 (1) Department of Anatomy, College of Medicine, Chung-Ang University, 221 Heukseok-Dong, Dongjak-Gu, Seoul, 156-756, Korea (2) Department of Thoracic and Cardiovascular Surgery, College of Medicine, Chung-Ang University, 221 Heukseok-Dong, Dongjak-Gu, Seoul, 156-756, Korea Received: 7 June 2005 Accepted: 20 June 2005 Published online: 21 October 2005 Summary Despite in vivo studies suggesting an important function for nitric oxide (NO) in the spinal cord in the transmission of pain signals, sympathetic nerve activity and presumably other spinal functions, changes of neuronal NO synthase (nNOS)-containing neurons with aging in the spinal cord has not been investigated. In the present study, we demonstrated for the first time that the number of nNOS-immunoreactive neurons was significantly decreased in the central autonomic nucleus and the superficial dorsal horn of spinal cord in aged rats. Morphologically, the number and length of dendritic branches also seemed to be decreased. Combined with our previous studies, age-related decreases in the number of nNOS-immunoreactive neurons in the central autonomic nucleus and the superficial dorsal horn might be associated with the abnormality of micturition function or pain perception encountered in the elderly. However, the mechanisms underlying the decreased immunoreactivity for nNOS, and the functional implications require elucidation. |
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